March 20, 2015

Patients with CF (cystic fibrosis) and chronic Pseudomonas aeruginosa lung infection have increased oxidative stress as a result of an imbalance between the production of reactive oxygen species caused by inflammation and their inactivation by the impaired anti-oxidant systems.  The effect of 4 weeks of oral N-acetylcysteine (NAC) 1200mg twice a day on 21 patients, 11 in the NAC group and 10 in the control group. The results included decreased levels of oxidized Vitamin C and increased the level of Vitamin C without significant improvement after 30 days.

Here is the link to the entire article:

Short-term, High-dose N-Acetylcysteine Improves Markers of Oxidative Stress in Cystic Fibrosis Patients with Chronic P. aeruginos Infection

God bless you and to your good health!

Joyce Gibb MS, CRNP
Ask The Pharmacist Group, LLC