A Legacy of Excellence
Nearly two decades ago, our founder, Joe DiMatteo Sr., looked at the existing probiotic landscape and saw a problem: products weren't surviving the shelf, let alone the stomach. Driven purely by clinical data, he formulated Probiotic Essentials—a groundbreaking, shelf-stable formula that set a new standard for what a probiotic could achieve.
At the time, the goal was to provide the gut with sufficient quantities of healthy bacteria that could colonize and restore gut health to proper function. It was a novel concept that medical community largely dismissed. Joe was an "influencer" long before that was a term. He saw that leaky gut was a very real problem hurting millions. He looked at the research available and created a solution that has helped thousands of people.
Innovation Driven By Research
The science has evolved. We now know probiotics do not permanently move into your gut to replace lost strains. Instead, they act as a temporary task force that disarms bad bacteria and calms inflammation so your body can do its job. They've been shown to improve IBS (2023 Meta-analysis of 72-RCT), improve sleep quality, and reduce anxiety & depression (2025 Meta-analysis of 72-RCT), and alleviate diarreha associated with antibiotic use (2021 Meta-Analysis of 42-RCT). And that's just for starters!
Just like their father, Joey & Dante saw excellent research like this and knew some changes needed to be made.
The Advanced Advantage
So what's changed with Probiotic Advanced Essentials?
Fewer Strains, Higher Efficiency
• Shifted from 11 strains down to 6 strains to eliminate "thin distribution" (where many strains were under 1 billion CFU and diluted).
Increased, Targeted CFU Count
• Upgraded from 12 billion total CFUs to 20 billion targeted bacterial CFUs.
The Addition of Saccharomyces boulardii
• Added 3 billion CFUs of S. boulardii—a specialized, clinically studied probiotic yeast that directly neutralizes harmful toxins (like those in C. diff), prevents pathogens from binding to the gut wall, and lowers gut permeability under stress.
Uncompromised Delivery & Stability
• Retained the industry-leading freeze-dried stability and delayed-release enteric-coated capsules perfected by Joe Sr., verified by independent third-party assays up to and beyond the expiration date.
We don't change formulas to chase health trends; we change them when the human data demands it. That's what Joe always did. That's the legacy we're continuing.
If you'd like to learn more, watch the episode 98 of Generation Health for a deep dive on the latest probiotic research. Once you're caught up, go pick-up a bottle of the new Probiotic Advanced Essentials, and help your gut get back on track!
