UA-Redux Essentials-(Uric Acid Redux Essentials)

Benefits

Vitamin C

Vitamin C has long been known for its benefits in supporting the immune system. Vitamin C must be obtained from food because the human body cannot manufacture this nutrient. In a meta-analysis of randomized controlled trials containing 1013 participants, pooled findings showed that vitamin C supplementation has a significant impact on lowering serum uric acid levels. Furthermore, a 20-year study published in the Archives of Internal Medicine that including almost 47000 males found that those taking vitamin C had a 44% reduced incidence of uric acid.

Quercetin Dihydrate

Quercetin is an important dietary polyphenol, a family of micronutrients that includes flavonoids, which have potent antioxidant properties and help to maintain normal inflammatory balance. It also acts as an immune regulator that may reduce the development of cellular oxidative damage. Quercetin is found in a variety of botanicals as well as vegetables and fruits, including apples, berries, onions, broccoli, and green leafy vegetables. Quercetin inhibits advanced glycation end products (AGEs), which are harmful oxidative byproducts formed in the body because of overactive chemical reactions. Most importantly, quercetin has been shown to inhibit the actions of xanthine oxidoreductase (XOR), which is the rate-limiting step in the body’s production of uric acid. In a prominent 2016 study of healthy adults, a month of daily quercetin at 500 mg resulted in significantly lowered uric acid levels. Additionally, a study of individuals at risk for cardiovascular challenges showed a statistically significant effect of quercetin supplementation in maintaining blood pressure within the normal range.

Luteolin

Luteolin is naturally concentrated in many fruits and vegetables, such as citrus fruits, broccoli, and green peppers, and herbs, such as thyme, rosemary, and oregano. Certain bioactive compounds in these plants and herbs inhibit the XOR enzyme. In fact, luteolin has been shown to have uric acid-lowering properties comparable to traditional therapies. In a 2017 double-blind, placebo-controlled study of people with uric acid, it was found that ingestion of luteolin for four weeks reduced serum uric acid levels. Flavonoids are further known for their ability to help maintain normal inflammatory balance and antioxidant properties, and luteolin, specifically, has been shown to be liver protective against uric acid free radical stress.

Tart Cherry

Tart cherries are known to contain anthocyanins and are believed to have many health benefits, including reducing oxidative stress and uric acid levels. One study shows that a low dose of tart cherry powder decreasing serum uric acid and supporting kidney function. Additionally, a 2021 study with 48 participates found that tart cherry ingestion can transiently decrease uric acid and a single powdered capsule is most effective for lowering uric acid.

Xanthine Oxidase Inhibitors: Celery Seed Extract and Apple Polyphenols

Celery is an umbelliferous plant that has been shown to reduce uric acid levels and help maintain normal inflammatory balance. Specifically, celery seed in an aqueous extract (CSAE) has been shown to reduce the levels of XOD. In addition, CSAE reduced the levels of reactive oxygen species and increased the serum levels of superoxide dismutase and glutathione peroxidase. More so, in a randomized, double-blind, parallel placebo-controlled clinical trial involving 62 volunteers randomized to 300 mg of apple polyphenols extract found a positive effect on vascular oxidative stress, endothelium function, and maintenance of healthy blood sugar levels by inhibiting XOD.