The Effect of Short-term NAC on Oxidative Stress Markers in Cystic Fibrosis

March 20, 2015

Patients with CF (cystic fibrosis) and chronic Pseudomonas aeruginosa lung infection have increased oxidative stress as a result of an imbalance between the production of reactive oxygen species caused by inflammation and their inactivation by the impaired anti-oxidant systems.  The effect of 4 weeks of oral N-acetylcysteine (NAC) 1200mg twice a day on 21 patients, 11 in the NAC group and 10 in the control group. The results included decreased levels of oxidized Vitamin C and increased the level of Vitamin C without significant improvement after 30 days.

Here is the link to the entire article:

Short-term, High-dose N-Acetylcysteine Improves Markers of Oxidative Stress in Cystic Fibrosis Patients with Chronic P. aeruginos Infection

God bless you and to your good health!

Joyce Gibb MS, CRNP
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