Probiotic PRO SPORE IG is a spore-based, broad-spectrum probiotic formula designed to promote a healthy gut microflora, protect mucosal integrity, and relieve small intestinal bacterial overgrowth (SIBO). Uniquely included in this formula are serum-derived bovine immunoglobulins that bind to and eliminate microbes and toxins that are common in SIBO. CLINICAL APPLICATIONS • Helps Maintain Normal Gastrointestinal Balance • Provides Concentrated Immunoglobulins to Enhance Mucosal Immunity • Supports Digestion and Micronutrient Absorption • Maintains GI Barrier Health and Integrity Probiotic PRO SPORE IG is a spore-based, broad-spectrum probiotic formula designed to promote a healthy gut microflora, protect mucosal integrity, and relieve small intestinal bacterial overgrowth (SIBO). Each capsule provides key Bacillus sporeforming probiotic strains that remain in a dormant protective state in the harsh gastrointestinal environment yet become active on target to colonize and recondition the gut. Uniquely included in this formula are serum-derived bovine immunoglobulins that bind to microbes and toxins that are common in SIBO, for elimination. OVERVIEW SIBO is a condition that occurs when there is an overabundance of commensal bacteria from the colon present in the small intestine. SIBO is largely overlooked and more prevalent than previously thought. The health of the small intestines relies on balanced microbiota, and probiotics and immunoglobulins can contribute to that balance by having a positive influence on the intestinal environment, including pH, organism diversity, and immune signaling. SIBO remains an area of research, but it is understood that dysbiosis and motility are key components. Such dysbiosis of the small intestine can be attributable to low stomach acid, medications, or alcohol consumption. Probiotics have been extensively studied and are characterized as having broad GI and immune benefits, including increasing the population of healthy bacteria following microflora imbalance; supporting healthy bowel function; increasing the production of short-chain fatty acids, which provide energy to the cells of the intestinal lining; strengthening the gut-immune barrier by promoting a healthy gut mucosa; aiding in the digestion of compounds like lactose and casein; and enhancing detoxification of harmful compounds. Probiotics are live organisms and must be shelf stable through the expiration date, so they can be precisely delivered to the intestinal tract to have maximum benefit. Bacillus spores can transition between a dormant and an active form, depending on the environment. Bacillus spores remain dormant in harsh environments until they reach more favorable environmentslike the human gastrointestinal tract. In its dormant spore form, Bacillus surrounds itself with an endospore, which is a tough,natural outer shell that protects it from light, heat, pressure, acid, lack of oxygen, and other environmental factors. Bacillus changes into its active form in the large intestine to colonize the gut to encourage microbial diversity of commensal gut bacteria. In its active form, Bacillus can increase microbial diversity by changing the pH, and increasing the production of short-chain fatty acids. The combination of specific strains, particularly Bacillus coagulans, Bacillus clausii, and Bacillus subtilis, relieve symptoms for common GI complaints and reinforce healthy gut function. The discovery that the gut barrier plays a key role in immune health fueled the search to strengthen it. Research has shown that the binding capabilities of immunoglobulins have a positive effect on gut barrier function. In the search for innovative ways to improve microbiome diversity, we have combined our blend of spore-forming probiotics alongside immunoglobulins uniquely shown to bind to bacteria and toxins, driving immune response. IgG helps to maintain a healthy intestinal immune system by binding a broad range of microbes and toxins within the gut lumen. As these unwanted triggers are removed, it resets healthy immune tolerance and builds a stronger barrier to the external environment in the gut. Serum-derived bovine immunoglobulins have the highest IgG concentration available for GI and immune challenges where allergens are a significant concern. Directions: 3 capsules per day or as recommended by your health care professional. Does Not Contain Wheat, gluten, soy, corn, dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners or preservatives. Caution: If you are pregnant or nursing, consult your physician before taking this product.