Neuro-P Advanced Essentials- Our newest combination product for peripheral neuropathy. Neuro P Advanced Essentials may be beneficial for: • Diabetic peripheral neuropathy • Nerve damage Neuro-P Advanced Essentials is a comprehensive formula containing B vitamins, acetyl L-carnitine and alpha-lipoic acid, designed specifically to address neuropathic pain by decreasing pain and supporting nerve regeneration. There is currently no effective pharmacologic treatment protocol for preventing or reversing neuropathic changes or to provide pain relief. Treatment of peripheral diabetic neuropathy is based primarily on intensive glycemic control. Glycemic control may help delay the onset of diabetic neuropathy or slow its progression in patients with type 2 diabetes, but it does not completely prevent the worsening of nerve damage. Complications of diabetic neuropathy typically continue their natural course, resulting in increased pain and discomfort, and loss of sensation. Pharmaceutical interventions are lacking for this painful, progressive condition, but clinical trials have demonstrated that the use of specific nutrients may help alleviate symptoms of neuropathy and also improve sensation, blood flow and nerve regeneration. The ingredients in Neuro-P Advanced Essentials help support healthy nerve tissue and may indirectly influence diabetic neuropathy by improving glycemic control and insulin sensitivity. Our first product to contain Benfotiamine. Experimental models of diabetes support a protective role for benfotiamine in preventing neuropathy and other diabetic complications. Benfotiamine (S-benzoylthiamine O-monophosphate) is a derivative of thiamine, which is metabolized into lipid-soluble S-benzoylthiamine. Plasma levels of thiamine may be as much as five times higher after oral supplementation with benfotiamine, which has three times higher bioavailability than thiamine HCl, and diabetics are often deficient in thiamine.(The lipid solubility of benfotiamine may account for its better retention compared to water-soluble thiamine.) Higher plasma levels of benfotiamine may help reduce the formation of AGEs, which could delay or reduce the progression of diabetic complications, including neuropathy, which may be caused in part by glycation damage to nerve tissue. Rat models of diabetes show that benfotiamine supplementation prevented tissue AGE accumulation and increased urinary excretion of protein glycation precursors. Benfotiamine, but not thiamine, has been shown to produce these results. Looking at data in humans, oral benfotiamine supplementation in subjects with type 1 and type 2 diabetes resulted in significant reductions in perceived pain due to polyneuropathy. Subjects with DPN who were treated with benfotiamine and B6 showed substantial improvements in allodynia and hyperpathy, as well as objective measurements of nerve conduction, with 86% of subjects rating their overall condition as having improved. Recommended Use: As a dietary supplement, take four capsules per day (two twice a day), or as directed by your health care practitioner (divided dosing recommended).