Methylfolate Essentials 800mcg Cherry Flavored Helps Support Nervous System and Cardiovascular Health Methylfolate (5-MTHF) is the most biologically active form of folate in the human body. Unlike folic acid, it needs no enzymatic conversion within the body, and is therefore six times more bioavailable. Many people suffer from a genetic disorder that prevents them from adequately converting folate into 5-MTHF. Since it does not require conversion, supplemental 5-MTHF quickly increases both blood and cellular levels of this critical nutrient†. In addition to its well-known role in supporting healthy fetal neural development, 5-MTHF is important in the synthesis of acetylcholine, an important neurotransmitter. 5-MTHF also supports a healthy cardiovascular system by helping to keep homocysteine levels within the normal range. Homocysteine is a known risk factor for cardiovascular disease.† * Quatrefolic is a registered trademark of Gnosis S.p.A.