(FORMERLY INFLAMMACORE AND GI PRO) We are always reviewing the latest scientific research so we can continue to deliver products that get results to our practitioners. Recently, new turmeric research with significant clinical implications caught our attention. It is well-known that turmeric, specifically curcumin, the primary standardized compound of turmeric, is poorly absorbed in the GI tract. Exciting new research shows the non-curcuminoid compounds of turmeric interact with the gut microbiota and play a key role in turmeric’s clinical benefits. As the research demonstrates, the gut microbiota may be the primary target of turmeric and all its compounds. We are pleased to announce that InflammaCORE will now contain our new turmeric raw material, Complete Turmeric Matrix (CTM), which contains 45-55% curcuminoids, 3-8% volatile oils, and 2-6% turmerin protein for improved clinical efficacy for even better patient results. FOR USE IN THE FOLLOWING CONDITIONS: LEAKY GUT IR BOWEL IBD AUTO IMMUNE DISEASES INFLAMMATION CLINICAL APPLICATIONS Maintains Normal Inflammatory Balance Strengthens GI Barrier Function Boosts Immune Function Provides Key Nutrients for Cell Replication Increases Antioxidant Protection OVERVIEW Inflammation is a natural part of the body’s immune response, a cascade triggered to protect the body and maintain normal tissue repair. Acute inflammation is the body’s initial response to harmful stimuli in which plasma and immune cells are relocated from the blood into injured tissues. This movement is followed by a cascade of biochemical events which advance the normal inflammatory response. When inflammation is prolonged, it leads to a progressive shift in the type of cells present at the site of inflammation and is characterized by simultaneous destruction and healing of the tissue. It is essential to maintain normal inflammatory balance to achieve optimal health. Suggested Use: Mix 2 scoops (51.8 grams) of Essential INFLAM Support with 8-10 ounces of the beverage of your choice to the desired thickness, once daily or as recommended by your health care professional. INGREDIENT BENEFITS Turmeric (Complete Turmeric Matrix) Whole-root turmeric and its active components have been used in traditional Ayurvedic medicine for centuries. In herbal medicine of old, practitioners used teas, tinctures and extracts of all types. In the 21st century, as research grew on the benefits of turmeric, the focus shifted to identifying and isolating one individual compound, curcumin, rather than delivering the comprehensive benefits of a matrix of turmeric bioactives. As a result, concentrating curcumin led to poor absorption and pharmaceutical methods were applied to bypass the gut and increase its bioavailability. The glaring disadvantage of applying this pharmaceutical model to botanicals is that it misses the benefits of other bioactives present within the turmeric matrix and their positive effects on the microbiome. New research on turmeric shows the additional bioactives in turmeric have additional benefits and enhance bioavailability. The Complete Turmeric Matrix includes compounds from the entire turmeric root, all working together as nature intended to deliver better results. The Complete Turmeric Matrix formulation contains standardized amounts of 45%–55% curcuminoids, 2%-6% turmerin protein and 3%-8% volatile oil, plus other components that make up the whole turmeric root. This matrix of bioactive compounds supports a healthy GI tract, creates a healthy microbiome, and helps maintain normal inflammatory balance Studies have shown that turmeric and its phytonutrients, like curcumin, specifically maintain normal inflammatory balance in the most significant GI challenges.1,2 Curcumin has been found to both promote GI mucosal health and help reduce stomach lining discomfort. It provides antioxidant protection in the cardiovascular system. Curcumin has also been shown to improve mood imbalances and adrenal fatigue by supporting a normal immune response, reducing oxidative stress and intestinal permeability. Green Tea Extract (EGCg) Green tea, used for centuries as a health tonic, is a potent antioxidant and is effective for maintaining normal inflammatory balance. Its most researched active component, EGCg, has been repeatedly shown to protect against free radical damage and balance markers of inflammation. Arabinogalactan Larch arabinogalactan is a fermentable polysaccharide fiber from the larch tree that promotes optimal immune health by supporting the growth of beneficial gut flora and strengthening the activity of NK cells. Skullcap Root Extract This popular Chinese botanical has been shown to maintain normal inflammatory balance and support cardiovascular health. Skullcap possesses potent antioxidant properties. Research has shown it attenuates NFkB and inhibits COX-2 expression. Quercetin A flavonoid found in a variety of botanicals, vegetables and fruits, quercetin is a potent antioxidant that inhibits inducible ICAM-1 expression, an important pathway for maintaining normal inflammatory balance. It has also been shown to enhance epithelial barrier function in the intestines by stabilizing mast cells through the release of cell-protective factors. Glutamine and Glycine Amino acids L-glutamine and glycine are essential for healthy gut mucosa and normal tissue repair. Numerous studies have shown these amino acids to be soothing to the GI lining. The amino acid L-glutamine have been associated with better immune response, stronger intestinal wall lining and higher antioxidant capacity. Recent research also highlights the synergistic role between these amino acids and a healthy balance of probiotic bacteria in the GI tract. Vitamin D One of the key functions of vitamin D is its ability to tighten gap junctions in the intestinal lining to create a strong barrier that protects the body from foreign substances. Recent research suggests that improving vitamin D status significantly affects the expression of genetic pathways linked to immune activity. Vitamin D up-regulates specific genes that increase cellular production of natural compounds that protect us against pathogens. Higher blood levels of vitamin D have been shown to enhance immune function and soothe tissues of the GI tract.