D Plus 45 Essentials Supplementing vitamin D3 and K2 can help promote bone health and maintain health cardiometabolic function. CLINICAL APPLICATIONS Supports Healthy Calcium Balance Promotes Bone Health Supports Cardiovascular Health and Arterial Elasticity Boosts Immune Function OVERVIEW New research is focusing on the synergistic relationship between vitamin K2 and vitamin D3, for bone and cardiovascular health. A group of naturally occurring and structurally similar, fat-soluble vitamins, vitamin K is essential for the proper utilization of calcium. Through its activation of the protein osteocalcin, vitamin K helps to bind newly absorbed calcium to the mineral matrix in bone. In addition, vitamin K has been found to help maintain bone mineral density by decreasing the activity of osteoclasts, a cell that breaks down the bone matrix. Vitamin K also provides critical cardiovascular protection by helping to activate matrix Gla protein (MGP), an inhibitor of circulatory calcification. Thus, vitamin K and vitamin D not only share similar qualities, but they also act synergistically within the body. The addition of MenaQ7® PRO to this formula is backed by extensive research. Dr. Leon Schurgers, world-renowned expert in vitamin K2 as MK-7 research for cardiovascular and bone health, and his team of research scientists have conducted over 15 clinical trials on MenaQ7® PRO through the University of Maastricht. Vitamin K2 with D3 includes 45 mcg of MenaQ7® PRO, the most widely studied form of vitamin K2 as MK-7, and 5,000 IU of vitamin D3 per capsule for optimal absorption and use by the body. Suggested Use: 1 or more capsules per day or as recommended by your health care professional INGREDIENT BENEFITS Vitamin K Depletion Although most people consume adequate dietary vitamin K to maintain sufficient blood clotting, most do not consume enough to meet cardiovascular and bone health needs. In fact, approximately 70% of the western population is deficient in vitamin K2. Bone Health Building and maintaining healthy bones requires a number of key nutrients including vitamin K, for the proper binding of calcium to the bone matrix. Cardiovascular Health and Blood Sugar Balance Vitamin K plays a key role in supporting the cardiovascular system as well as blood sugar balance already within normal levels. Immune Modulation New evidence also suggests vitamin K plays a central role in boosting immune function.