SereVive 120 Capsules FORMERLY CEREVIVE CAPSULES (BY ORTHO MOLECULAR) Stress resilience and maintaining a positive mental outlook are two factors that are as important to our health as eating a healthy diet. SereVive is formulated to support these factors and promote a relaxed, focused state. Designed to Support Mood and Brighten Mental Outlook Supports the Production of the Neurotransmitters Serotonin, GABA, Dopamine, Norepinephrine and Epinephrine Supports Calming Alpha Brain Wave Activity Addresses Neurotransmitter Signaling Systems L-Theanine L-theanine is an amino acid found abundantly in green tea. L-theanine has been shown to quickly improve stress perception and resilience. The stress-buffering mechanisms of L-theanine have been connected to its ability to increase serotonin and dopamine production in the brain. L-theanine has also been shown to significantly increase alpha brain wave activity, which is critical for increasing attention as well as promoting a sense of relaxation. PharmaGABA® Gamma-amino butyric acid (GABA) is one of the major inhibitory neurotransmitters in the brain. GABA provides a calming effect and is a primary component of the body’s stress fighting mechanisms. GABA is also available as dietary supplement. Most commercially available forms of GABA utilize synthetically-produced GABA, manufactured from pyrrolidinone, a compound not allowed for use in Japan. SereVive includes a patented, naturally-sourced, non-synthetic form of GABA called PharmaGABA®. It is produced naturally by the friendly bacteria,Lactobacillus hilgardii. In contrast to synthetic GABA sources, PharmaGABA® has been shown in published research studies to promote relaxation effects in the central nervous system (CNS). Inositol Inositol is a B vitamin that is an important component of cell membrane signaling. As part of the cellular signaling system of the CNS, inositol is crucial for the release of neurotransmitters from within the nerve cells. A deficiency of inositol can affect brain signaling, resulting in inadequate neurotransmitter release causing irritability, worry and restlessness. 5-HTP 5-hydroxytryptophan (5-HTP) is an amino acid intermediate that is directly converted into the mood-regulating neurotransmitter, serotonin. Maintaining a healthy serotonin level is important regulating appetite and sleep cycle and for supporting a sense of calmness. As a dietary supplement, 5-HTP is produced naturally from the seeds of the African plant, Griffonia simplifolia. In contrast to L-tryptophan, 5-HTP provides efficient conversion into serotonin because it does not need prior conversion by tryptophan hydroxylase. L-Tyrosine L-tyrosine is an amino acid precursor to the neurotransmitters dopamine, norepinephrine and epinephrine. These neurotransmitters help regulate mood, memory and concentration. L-tyrosine is able to cross the blood-brain barrier by the large neutral amino acid (LNAA) carrier system that is present in brain capillaries. Supplementation with L-tyrosine helps to increase the concentration of available tyrosine and reduce competition among similar amino acids. Once taken up by nerve cells, tyrosine is converted to L-dopa, then to dopamine. Dopamine is either used as a neurotransmitter or as a precursor to produce norepinephrine and epinephrine. Mucuna pruriens Mucuna pruriens, commonly known as Velvet bean, includes standardized doses of L-dopa. L-dopa is the direct precursor to the neurotransmitter dopamine, which helps maintain a positive mental outlook, and motivation. It is also important for supporting cognitive function. Supplementation with M. pruriens has been shown to support neurotransmitter production. In a study of 75 men, M. pruriens supplementation significantly improved dopamine, norepinephrine and epinephrine levels compared to the control group. Micronutrients SereVive includes several nutrients that are required in synthesis pathways for the neurotransmitters serotonin, GABA, dopamine, norepinephrine and epinephrine. This includes 5-methyltetrahydrofolate (5-MTHF), vitamin B6, vitamin C, zinc and magnesium. 5-MTHF is the biologically active form of the B vitamin folic acid, which is vital to supporting proper mood regulation. 5-MTHF works together with B12 as methyl group donor. Methyl (CH3) group donation is important for maintaining neurotransmitter synthesis. Magnesium is a mineral that calms the nervous system by binding to glutamate receptors, which reduces excitatory neurotransmitter activity.