Overview Berberine Advanced Essentials combines 400 mg of the plant alkaloid berberine (from Berberis aristata) for the primary purpose of supporting healthy blood sugar levels and enhancing insulin sensitivity. Additionally, berberine has been shown to exhibit antimicrobial properties. Berberine Advanced Essentials is manufactured using the Designs for Health Evail™ technology, which is an all-natural formulation that improves the absorption and delivery of berberine. This process uses a proprietary blend of MCT oils, non-soy derived lecithin, and vitamin E, without the use of potentially harmful surfactants. Made with non-GMO ingredients.