PPI’s and Magnesium posted on November 4, 2014 MagnesiumPPIproton pump inhibitors Share this Post Share on Twitter Share on Facebook Share on Google Plus November 4, 2014 Proton pump inhibitors (PPI) can lower blood magnesium. This has been recognized since 2006. Two men and two women using a PPI developed severely lowered magnesium levels, lowered calcium, relative hypoparathyroidism and extremely low urinary calcium / magnesium. One had brain injury due to low oxygen probably due to a collapse after an abnormal heart rhythm. Others had EKG abnormalities. The study showed that the PPI induced low magnesium that this is a generic effect and may occur within one year of PPI therapy. Here is a link to the article: A Case Series of Proton Pump Inhibitor-induced Hypomagnesemia God bless you and to your good health! Joyce Gibb MS, CRNP Acid Block (60) $25.99 Add to cart No ratings.