Can Opioid Consumption Decrease DHEA? posted on January 19, 2015 deficiencyDHEAopioid Share this Post Share on Twitter Share on Facebook Share on Google Plus January 19, 2015 This article in the Journal of Pain studied DHEA in opioid and non-opioid users. DHEA (dehydroepandrosterone) levels were lower in opioid consumers than in control subjects. Sixty-seven % of opioid users and 8% of non-opioid users DHEA levels were below age specific norms. ACTH (Adrenocorticotropic hormone) levels were normal and unrelated to opioid use. DHEA deficiency often produces fatigue, depression, weakness and sexual dysfunction which improve during replacement therapy. Here is the link to the article: DHEAS Deficiency During Consumption of Sustained-action Prescribed Opioids: Evidence For Opioid-induced Inhibition of Adrenal Androgen Production God bless you and to your good health! Joyce Gibb MS, CRNP Ask The Pharmacist Group, LLC DHEA 25mg (120) $36.99 Add to cart No ratings. DHEA 25 mg (60) $11.99 Add to cart No ratings.