Can Opioid Consumption Decrease DHEA?

January 19, 2015

This article in the Journal of Pain studied DHEA in opioid and non-opioid users.  DHEA (dehydroepandrosterone) levels were lower in opioid consumers than in control subjects.  Sixty-seven % of opioid users and 8% of non-opioid users DHEA levels were below age specific norms.  ACTH (Adrenocorticotropic hormone) levels were normal and unrelated to opioid use.  DHEA deficiency often produces fatigue, depression, weakness and sexual dysfunction which improve during replacement therapy.

Here is the link to the article:

DHEAS Deficiency During Consumption of Sustained-action Prescribed Opioids:  Evidence For Opioid-induced Inhibition of Adrenal Androgen Production

God bless you and to your good health!

Joyce Gibb MS, CRNP
Ask The Pharmacist Group, LLC



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